Iran Press/ Middle East: An Israeli military spokesperson declined to comment on the reports. The Syrian reports did not mention any casualties.
Israel has mounted frequent attacks against targets in Syria.
Citing a military source, state news agency SANA said Israel had mounted an "aerial aggression" at 1:23 a.m., firing a number of missiles targeting the container storage area at the port and setting some on fire.
A source familiar with port operations said it was the first time Israel had attacked the facility on Syria's Mediterranean coast.
Images posted by SANA showed flames and smoke in the container area and a fire truck at the scene.
Ismail Hilal, the governor of Latakia, said firefighters had put out the flames and were working to cool the site, SANA reported. State television said five explosions rocked the city.
Last month, Syrian state media reported four Israeli attacks.
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