Iran Press/ Asia: The crash involved a Boeing 737 travelling from Kunming to Guangzhou.
Broadcaster CCTV said the crash occurred near the city of Wuzhou in Teng county.
The number of casualties is not immediately known and rescue teams are on the way, CCTV said.
According to FlightRadar24 data, the flight tracking ended at 2.22pm (6.22am GMT) at an altitude of 3,225ft with a speed of 376 knots.
China's last fatal jet accident was in 2010, when 44 of 96 people were killed when an Ambraer E-190 regional jet flown by Henan Airlines crashed on approach to Yichun airport in low visibility, according to Aviation Safety Network.
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