Iran Press/ Europe: Ferran Torres scored two goals in the first half for Spain, the second coming after Leonardo Bonucci was sent off for a second yellow card three minutes before the break.
Lorenzo Pellegrini pulled one back for Italy late on as the Azzurri threatened an improbable comeback.
In the end, though, Roberto Mancini’s side fell to its first loss in more than three years.
Spain will face either world champion France or top-ranked Belgium in the final in Milan on Sunday.
The UEFA Nations League is a biennial international football competition contested by the senior men's national teams of the member associations of UEFA, the sport's European governing body.
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Italy beat Spain 4-2 on penalties to enter final