At least 46 people have died after an earthquake hit China's southwestern Sichuan province on Monday, Chinese broadcaster CCTV reported.

Iran PressAsia: A 6.6-magnitude earthquake with a depth of 10 kilometers (6 miles) was reported southwest of Sichuan's capital Chengdu close to 1 p.m. local time on Monday, the United States Geological Survey (USGS) reported.

The quake's epicenter was about 43 kilometers (27 miles) southeast of Kangding, a city of around 100,000 people, according to the USGS.

At least 50 people were also injured and 16 others remain missing, CCTV reported.

Over a million residents in surrounding areas are estimated to have experienced moderate tremors in the aftermath of the quake, it added.

China activated a Level 3 emergency response and dispatched rescue workers to Luding County near the epicenter, according to China's State Council. Chinese broadcaster CGTN said rescue workers were helping to clear roads blocked by landslides triggered by the quake.