The demonstrators gathered at Cottbus city hall on Sunday where they chanted and sang, calling on German Chancellor Angela Merkel to resign.
The German city has seen a spate of violent attacks involving refugees.
Anti-migrant demonstrators were seen holding banners reading "Merkel must go" referred to German Chancellor Angela Merkel's decision to allow almost one million refugees to settle in Germany during the 2015 migrant crisis.
The number of new arrivals has since dropped dramatically.
