The appointment of Hunt, the long-serving health minister, sees a close May ally replace the maverick Johnson, and could alter the Brexit balance of May's top ministerial team.
While Johnson was one of the most high-profile Brexit campaigners, Hunt backed "Remain" during the 2016 referendum campaign. Hunt told LBC Radio in October 2017, however, that he had changed his mind on the issue, in part because of what he said was disappointing "arrogance" in the EU's behaviour during negotiations.
Last month, Hunt said it was inappropriate for businesses like Airbus to issue warnings about moving jobs because of Brexit and that they should instead be getting behind May in her push for a good deal on leaving the EU.
On Monday, Johnson became the third minister in 24 hours to quit the government rather than back May’s strategy for Brexit.