"We reject the accusations behind Venezuelan President Nicolas Maduro’s decision to expel our diplomats. Disappointed, but not surprised," Pompeo said on his Twitter.
On Tuesday, the Venezuelan government declared US Charge d'affaires Todd Robinson and Deputy Head of Mission Brian Naranjo to be personae non grata and ordered their expulsion from the country.
The tension in the relations between the two countries escalated following the presidential election in Venezuela held last Sunday.
Maduro was re-elected with over 65 percent of the vote.
However, US President Donald Trump has issued an executive order barring US citizens from buying debt from the Venezuelan government.