Iran Press/ Iran news: When the human body is injured, the skin repair process is metabolically active, requiring oxygen for the physiological processes associated with wound healing. In the case of chronic wounds, hypoxia (low oxygen conditions) can occur, delaying the healing process.
Research has shown that microneedle patches can improve the wound healing process. According to Sahab News, citing Mehr News Agency, a group of Iranian researchers have developed microneedle patches based on biodegradable gelatin methacrylate that are mechanically strong and capable of penetrating tissue. These patches release oxygen upon exposure to the body’s interstitial fluid and wound secretions.
In this research, the oxygen release rate and biocompatibility of the microneedle patches were evaluated and optimized using different combinations. Laboratory (in-vitro) tests demonstrated that the optimized patches could release oxygen at a therapeutic level, significantly improving the survival rate of hypoxic cells in chronic wounds by aligning them with cells in a normal oxygen environment.
Experiments on animals (in-vivo) also showed that the oxygen-releasing microneedle patches did not cause any harm or disruption to the healing process in severely wounded lab mice.
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