Fragments of the interview with the NTV station appeared on a messaging app site of Assad's office, Russian state news agency Tass reported Friday.
In it, Assad said "Negotiations with the U.S. now will not lead to anything, it's an empty waste of time. We are not going to talk to Americans just because they are Americans."
"We are ready to talk to anyone with whom we can achieve results, but we consider that U.S. policy will not change in the future," he was quoted as saying.
Thousands of men from the coastal region are believed to have been killed fighting for the government of Syria, since 2011.
Takfiri terrorists have been driven out of many towns and cities in Syria, with the government of popular president, Bashar al-Assad, now in control of Syria’s largest cities and its coastal region.
But,Syrian government forces have launched several intensive strikes on terrorist-held positions.
In a significant victory early last month, the Syrian army managed to fully liberate Eastern Ghouta, which had long been controlled by militant groups and served as a launch pad for deadly rocket attacks against residents and civilian infrastructure in the capital.