In a statement, the ministry said it was "deeply disappointed by the decision of US President Donald Trump to unilaterally refuse to carry out commitments under the Joint Comprehensive Plan of Action," adding that Washington's actions were "trampling on the norms of international law."
The ministry added it was open to further cooperation with other Iran deal members and would continue to actively develop bilateral ties with Tehran.
US President Donald Trump said on Tuesday that he was reimposing economic sanctions on Iran and pulling the United States out of an international agreement.
Iranian President Hassan Rouhani says Tehran will stay in the JCPOA with other signatories, stressing that Iran has always complied with its commitments to the JCPOA, while the US has never complied with its requirements.
European leaders decried Trump's decision to withdraw from the deal, which had lifted sanctions against Iran in return for curbs on its nuclear programme. They called on Washington not to take steps that would prevent other countries from upholding it.
Iran has on numerous occasions asserted that its nuclear program is merely peaceful and not meant to make nukes.
Since the accord between Iran and the six world powers was signed in Vienna in July 2015, the International Atomic Energy Agency (IAEA) has repeatedly confirmed Iran’s compliance with its commitments.