The protest is just the latest in months that have targeted the organization, stricter gun control laws and aim to increase voter registration after a string of mass shootings, stemming back to the high school attack in Parkland, Florida.
Protesters, including some from Marjory Stoneman Douglas High School, rallied outside the gun-rights organization and were met by several dozen of its supporters.
"Hey, hey, ho ho, the NRA has got to go," the crowds chanted while NRA supporters, some armed with weapons, waved President Donald Trump banners and held up signs, including one reading "Tyranny: When you disarm me."
Police officers, along with white and orange barriers separated the protesters from NRA supporters.
The protest was also held on the birthday of Joaquin Oliver, one of the 17 who died in the Florida high school shooting on Feb. 14. His father created a mural outside the gun lobby building and the crowd sang happy birthday.
As a part two of their #NeverAgain movement, Parkland students have been on a bus tour aimed at registering voters and ending gun violence.
They are protesting what they consider efforts by the NRA to block gun control laws and bans on assault rifles.
