Iran Press/Iran news: Iranian researchers introduced a novel treatment approach for bone repair using stem cells and brown seaweed In an international scientific collaboration performed by a team of researchers from Iranian biological resources, including Shahid Beheshti University, Kharazmi University, Dundee University, Mahatma Gandhi University, and Pasteur Institute of Iran led by Dr. Hosein Shahsavarani, a new treatment for bone regeneration has introduced using mesenchymal stromal cells and a natural nanofiber scaffold derived from brown seaweed extracted from the Persian Gulf.
In this study, which was inspired by natural structures capable of mimicking the niche of bone tissue, researchers could successfully cultivate, proliferate, and differentiate adipose-derived stem cells into bone cells in both in vitro and in vivo conditions for future clinical applications
The proposed innovative approach, which was carried out through the collaboration of various disciplines including cell science, biomaterials, marine biology, chemical engineering, and orthopedics, has efficient rates of bone regeneration obtained through chemical and physical induction using a sustainable scaffold.
"Surprisingly, we found remarkable synergistic effects between the physical properties of the decellularized seaweed scaffold and its chemical composition mainly due to the existence of Fucoidan in enhancing Osteogenesis" explains Professor Shahsavarani, the lead author of the study. This finding offers a feasible and safe system for bone repair and holds promise for future clinical applications in regenerative orthopedics.
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